Endocrine Abstracts

Primary hyperparathyroidism is characterized by abnormal PTH secretion from one or more hyperfunctioning parathyroids and hypercalcemia. PTH exerts a catabolic effect on the cortical bone resulting in the osteitis fibrosa cystica. Two patients were referred to us after destroyed surgery for brown tumors mistaken for primitive bone tumors.A 59 years old man was referred to emergency department for a pathologic fracture of the left hip. The X-ray showed a ...

Introduction: Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is an innovative method for the detection of primary tumours or metastases of thyroid cancer; however, recurrence or metastases of medullary thyroid carcinoma (MTC) are still difficult to detect.Aim: The objective of this study was to evaluate the clinical use of 18F-FDG PET in patients with MTC.Patients and methods: We enr...

Somatostatin analogues (SSA) have an established role in the medical management of patients with neuroendocrine tumours (NETs). They are effective in the symptomatic treatment of some metastatic NETs and may also provide tumour stabilisation or reduction. We report two patients with disease progression who benefited from SSA. Mrs HW, 64-year old woman, was diagnosed with a grade 1 small-bowel NET with lymph node and liver metastasis in 2012: Ki-67 index < 1%. Despite a seg...

Background: Primary thyroid angiosarcoma (PTA), previously considered a vascular type of anaplastic thyroid carcinoma (ATC), is a rare, aggressive malignant mesenchymal tumor, with a peak incidence in the seventh decade of life. PTA can present as an ATC, a more frequent type of thyroid malignancy. Differential diagnosis is of major importance, as the management and prognosis differ significantly.Case report: A 72-year-old woman presented for a 2 month h...

54 year old lady presented to the endocrine clinic. She was diagnosed with breast cancer and right ovarian tumour at the same time in August 2015. She had right lumpectomy of breast and Salpingo-Oophorectomy in November 2015. She was not feeling very well for the last few weeks. She complained of extreme lethargy and tiredness. She had blood test done on 15th November 2016 that showed prolactin level at 2849 nmmol/l with negative macroprolactin. Hence, she was referred to the ...

The stromal compartment changes with cancer, with an emergence in activated fibroblasts. These stromal changes, which occur with cancer initiation and throughout progression, are known to influence the hallmarks of cancer and are becoming increasingly studied for prognostic and therapeutic purposes. Androgen receptor (AR) signalling in stromal cells is important in prostate cancer and these cancer stromal communications, yet the mechanisms underpinning stromal AR contribution ...

Introduction: This audit aims to evidence the compliance of our practice with guidelines on the management of thyroid cancer. This may help to promote quality improvement in areas where there is substandard clinical care and service provision.Method: In this retrospective study, patients diagnosed with thyroid cancers at our unit between 2009 and 2014 were identified. Electronic records were examined to establish the dates of referral, clinic attendance,...

Introduction: Gestational diabetes mellitus (GDM) is a condition that occurs during pregnancy when the body cannot produce enough insulin to handle the effects of a growing baby and changing hormone levels. Numerous studies reported that an increased risk of GDM among women who are overweight or obese compared with lean or normal-weight women.Methods/design: The purpose of this study is to compare anthropometric and biochemical parameters in postmenopaus...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

Successful crystallization of TSHR residues 21–260 has been reported (Sanders et al. Thyroid 2007 17 395) using a partial ectodomain (ECD) bound to the Fab fragment of a human stimulating TSHR monoclonal antibody (M22) and its conformational epitopes delineated. We have now studied antibody binding to the entire ECD (residues 1–412) using epitope protection. In this approach, we first protected a highly purified ectodomain fragment with a variety...